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Ragupathy Renganathan
Ragupathy Renganathan
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MCQ Practice

Pharmacology MCQs with Answers and Explanations

Pharmacology MCQs are best learned by mechanism: once the receptor and pathway are clear, the drug class, use and adverse effect follow.

Each explanation gives that mechanism in one line.

10 free questions shown · 100 in the full test

Topics covered

  • Receptor pharmacology
  • Autonomic drugs
  • CNS and cardiovascular agents
  • Antimicrobials
  • Adverse drug reactions

10 Pharmacology MCQs with answers

  1. Q1

    Pharmacokinetics deals with:

    • AWhat the body does to the drug (ADME)
    • BWhat the drug does to the body
    • CDrug manufacture
    • DDrug formulation

    Explanation: PK = Absorption, Distribution, Metabolism, Excretion — what the body does to the drug.

  2. Q2

    Pharmacodynamics deals with:

    • ADrug effects and mechanisms
    • BDrug absorption
    • CDrug excretion
    • DDrug stability

    Explanation: PD = effects of drug on the body, including receptor interactions.

  3. Q3

    Beta-blockers act on:

    • Aα adrenergic receptors
    • Bβ adrenergic receptors
    • CMuscarinic receptors
    • DNicotinic receptors

    Explanation: Beta-blockers antagonize β-adrenergic receptors.

  4. Q4

    Paracetamol primarily acts by inhibiting:

    • ACOX in CNS
    • BACE
    • CBeta receptors
    • DH1 receptors

    Explanation: Paracetamol's analgesic/antipyretic effect involves central COX inhibition.

  5. Q5

    First-line drug for tuberculosis:

    • ARifampicin
    • BPenicillin
    • CMetformin
    • DAtenolol

    Explanation: Rifampicin (with INH, PZA, EMB) is first-line anti-TB therapy.

  6. Q6

    ACE inhibitors are used for:

    • AHypertension and heart failure
    • BDiabetes only
    • CAsthma only
    • DMigraine only

    Explanation: ACE inhibitors (e.g., enalapril) treat hypertension, heart failure, and nephroprotection.

  7. Q7

    Metformin's primary mechanism is:

    • ADecreases hepatic gluconeogenesis
    • BStimulates insulin secretion
    • CBlocks SGLT2
    • DInhibits DPP-4

    Explanation: Metformin acts mainly by reducing hepatic glucose production.

  8. Q8

    Aspirin irreversibly inhibits:

    • ACOX-1 and COX-2
    • BOnly COX-2
    • CACE
    • DHMG-CoA reductase

    Explanation: Aspirin acetylates COX-1 (and COX-2) irreversibly.

  9. Q9

    Therapeutic Index =

    • ATD50/ED50
    • BED50/TD50
    • CLD50 − ED50
    • DCmax/Tmax

    Explanation: Therapeutic Index = TD50/ED50 — higher = safer.

  10. Q10

    Atropine is a:

    • AMuscarinic antagonist
    • BBeta agonist
    • CAlpha agonist
    • DCalcium channel blocker

    Explanation: Atropine blocks muscarinic acetylcholine receptors.

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