Topics covered
- HPLC and GC
- Dissolution and disintegration
- Karl Fischer titration
- USP general chapters
- Method validation
10 Quality Control (QC) MCQs with answers
- Q1
HPLC stands for:
- AHigh Pressure Liquid Chromatography
- BHigh Performance Liquid Chromatography
- CHigh Phase Liquid Chemistry
- DHeated Pressure Liquid Compound
Explanation: HPLC = High Performance Liquid Chromatography.
- Q2
Which detector is most commonly used in HPLC for pharmaceuticals?
- AFID
- BUV-Visible
- CTCD
- DECD
Explanation: UV-Vis (PDA) detectors are most commonly used for drug analysis.
- Q3
Karl Fischer titration is used to determine:
- ApH
- BWater content
- CAssay
- DHeavy metals
Explanation: Karl Fischer is the standard method for moisture determination.
- Q4
USP <711> deals with:
- ADissolution
- BDisintegration
- CFriability
- DHardness
Explanation: USP <711> is the official chapter for Dissolution testing.
- Q5
Limit test for chloride uses:
- ASilver nitrate
- BBarium chloride
- CSodium hydroxide
- DPotassium iodide
Explanation: Chloride limit test uses silver nitrate to form silver chloride opalescence.
- Q6
Which is an example of a destructive test?
- AWeight variation
- BDissolution
- CVisual inspection
- DLabeling check
Explanation: Dissolution destroys the dosage form during testing.
- Q7
LOD in analytical methods stands for:
- ALoss on Drying / Limit of Detection
- BLevel of Determination
- CList of Drugs
- DLinearity of Data
Explanation: LOD = Limit of Detection (also Loss on Drying in other contexts).
- Q8
Which technique separates compounds based on mass-to-charge ratio?
- AIR
- BNMR
- CMass Spectrometry
- DUV
Explanation: Mass Spectrometry separates ions based on m/z.
- Q9
Friability test apparatus is:
- ARoche friabilator
- BMonsanto tester
- CErweka hardness tester
- DDisintegration tester
Explanation: Roche friabilator is the standard apparatus per USP <1216>.
- Q10
Acceptable friability limit for uncoated tablets is generally:
- ANMT 0.5%
- BNMT 1.0%
- CNMT 2.0%
- DNMT 5.0%
Explanation: Generally NMT 1.0% weight loss is acceptable per USP.
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