Topics covered
- UV-visible spectroscopy
- IR and NMR
- Mass spectrometry
- Chromatography
- ICH Q2 validation parameters
10 Pharmaceutical Analysis MCQs with answers
- Q1
Beer-Lambert law relates absorbance to:
- AConcentration and path length
- BTime
- CTemperature only
- DpH
Explanation: A = εcl — absorbance is proportional to concentration and path length.
- Q2
IR spectroscopy identifies compounds based on:
- AFunctional groups (vibrational transitions)
- BAtomic number
- CBoiling point
- DColor
Explanation: IR detects vibrational modes characteristic of functional groups.
- Q3
NMR spectroscopy primarily provides information about:
- AHydrogen / carbon environments
- BMolecular weight only
- CColor
- DDensity
Explanation: 1H and 13C NMR reveal chemical environments of nuclei.
- Q4
Which is a non-aqueous titration solvent?
- AWater
- BGlacial acetic acid
- CSaline
- DMethanol-water
Explanation: Glacial acetic acid is commonly used in non-aqueous titrations for weak bases.
- Q5
Potentiometry measures:
- APotential difference at zero current
- BCurrent at fixed potential
- CResistance
- DConductance
Explanation: Potentiometric titrations follow the potential change of an indicator electrode.
- Q6
Mobile phase in normal-phase HPLC is typically:
- APolar (water)
- BNon-polar (hexane)
- CBuffer only
- DAcid only
Explanation: Normal phase = polar stationary, non-polar mobile phase like hexane.
- Q7
C18 column is used in:
- ANormal phase HPLC
- BReverse phase HPLC
- CIon exchange
- DSize exclusion
Explanation: C18 (ODS) is the most popular reverse-phase stationary phase.
- Q8
Limit of Quantitation (LOQ) is typically defined as:
- ASignal-to-noise 3:1
- BSignal-to-noise 10:1
- CTwice the mean
- DHalf the LOD
Explanation: Per ICH Q2(R1), LOQ ≈ 10:1 S/N (LOD ≈ 3:1).
- Q9
Which is NOT an ICH validation parameter?
- ASpecificity
- BLinearity
- CColor
- DRobustness
Explanation: Color is not a validation parameter per ICH Q2(R1).
- Q10
UV cut-off of methanol is approximately:
- A205 nm
- B254 nm
- C280 nm
- D350 nm
Explanation: Methanol's UV cut-off is around 205 nm.
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